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Home - Products - PI3K/Akt/mTOR signaling - PDK - PS 423

PS 423

CAS No. 1221964-37-9

PS 423( PS423 )

Catalog No. M10841 CAS No. 1221964-37-9

PS 423 is a substrate-selective inhibitor of PDK1, inhibits the phosphorylation and activation of S6K.

Purity : >98% (HPLC)

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Biological Information

  • Product Name
    PS 423
  • Note
    Research use only, not for human use.
  • Brief Description
    PS 423 is a substrate-selective inhibitor of PDK1, inhibits the phosphorylation and activation of S6K.
  • Description
    PS 423 is a substrate-selective inhibitor of PDK1, inhibits the phosphorylation and activation of S6K without affecting the PKB/Akt signaling pathway in HEK293 cells, the prodrug of PS210; inhibits glucose uptake in C2C12 myoblasts; inhibits S6K but not PKB/Akt downstream signaling in muscle cells.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    PS423
  • Pathway
    PI3K/Akt/mTOR signaling
  • Target
    PDK
  • Recptor
    PDK
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1221964-37-9
  • Formula Weight
    524.445
  • Molecular Formula
    C25H23F3O9
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    O=C(OCOC(C)=O)C(C(C1=CC=CC=C1)CC(C2=CC=C(C(F)(F)F)C=C2)=O)C(OCOC(C)=O)=O
  • Chemical Name
    Bis(acetoxymethyl) 2-[3-oxo-1-phenyl-3-[4-(trifluoromethyl)phenyl]propyl]malonate

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Busschots K, et al. Chem Biol. 2012 Sep 21;19(9):1152-63. 2. Arkin MR, et al. Chem Biol. 2014 Sep 18;21(9):1102-14.
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